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Mtortm1.1Clyn
Targeted Allele Detail
Nomenclature
Symbol: Mtortm1.1Clyn
Name: mechanistic target of rapamycin (serine/threonine kinase); targeted mutation 1.1, Christopher Lynch
MGI ID: MGI:4820819
Gene: Mtor  Location: Chr4:148448611-148557683 bp, + strand  Genetic Position: Chr4, 78.76 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:162945
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre mediated recombination removed the neo cassette, exon 49, and the modified exon 50. Reduced protein expression was confirmed by western blot analysis on heart and liver extracts from heterozygotes. (J:162945)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mtor Mutation:  57 strains or lines available
References
Original:  J:162945 Lang CH, et al., Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine. Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1283-94
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory