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Ppp2r3atm1(KOMP)Mbp
Targeted Allele Detail
Nomenclature
Symbol: Ppp2r3atm1(KOMP)Mbp
Name: protein phosphatase 2, regulatory subunit B'', alpha; targeted mutation 1, Mouse Biology Program, UCDavis
MGI ID: MGI:4819992
Gene: Ppp2r3a  Location: Chr9:100982283-101128994 bp, - strand  Genetic Position: Chr9, 53.19 cM
Mutation
origin
Mutant Cell Lines:  DEPD00529_4_A05, DEPD00529_4_A06, DEPD00529_4_B05, DEPD00529_4_B06, DEPD00529_4_B07, DEPD00529_4_B08, DEPD00529_4_C06, DEPD00529_4_C08, DEPD00529_4_D05, DEPD00529_4_D06, DEPD00529_4_D07, DEPD00529_4_D08, DEPD00529_4_E05, DEPD00529_4_F07, DEPD00529_4_F08, DEPD00529_4_G05, DEPD00529_4_G06, DEPD00529_4_G07, DEPD00529_4_G08, DEPD00529_4_H05, DEPD00529_4_H06, DEPD00529_4_H07, DEPD00529_4_H08
Germline Transmission:  Earliest citation of germline transmission: J:211773
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsThe insertion of the L1L2_Bact_P cassette created a deletion of size 1745 starting at position 101070558 and ending at position 101072303 of Chromosome 9 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157064)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Ppp2r3a Mutation:  25 strains or lines available
References
Original:  J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory