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Targeted Allele Detail
Symbol: Cyldtm1.1Gmos
Name: CYLD lysine 63 deubiquitinase; targeted mutation 1.1, George Mosialos
MGI ID: MGI:4819959
Synonyms: Cylddelta9
Gene: Cyld  Location: Chr8:88697047-88751945 bp, + strand  Genetic Position: Chr8, 43.51 cM
Germline Transmission:  Earliest citation of germline transmission: J:162840
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neo cassette was inserted upstream of exon 9 and an additional loxP site was inserted downstream of exon 9. Cre mediated recombination removed the neo cassette and exon 9. This exon codes for an essential catalytic motif of the deubiquitination domain. The absence of protein expression was confirmed by western blot analysis on fibroblast extracts. (J:162840)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cyld Mutation:  22 strains or lines available
Original:  J:162840 Trompouki E, et al., Truncation of the catalytic domain of the cylindromatosis tumor suppressor impairs lung maturation. Neoplasia. 2009 May;11(5):469-76
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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