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Ptprca
Allele Detail
Nomenclature
Symbol: Ptprca
Name: protein tyrosine phosphatase, receptor type, C; a variant
MGI ID: MGI:4819849
Synonyms: CD45.1, Ly5a, PtprcSJL
Gene: Ptprc  Location: Chr1:138062861-138175708 bp, - strand  Genetic Position: Chr1, 60.73 cM
Mutation
origin
Strain of Origin:  Not Applicable
Mutation
description
Allele Type:    Not Applicable
Mutation:    Nucleotide substitutions
 
Mutation detailsPtprca is found in strains SJL/J, STS/A, and DA. Ptprcb is found in strains C57BL/6, C3H/An, DBA/2, AKR, and many others (J:13367, J:12054, J:12077, J:8603). Twelve nucleotide differences between the a and b alleles have been identified. These base substitutions correspond to five amino-acid changes within the extracellular domain of the encoded protein. These amino-acid differences are clustered in a region that also contains the greatest divergence between mouse and rat sequences (J:22485).

Note that the allele designations originally described were reversed in 1987 (J:8603); all publications prior to 1987 show SJL/J, STS/A, and DA as having the b allele and the C57BL/6J group as having the a allele (J:22341). (J:8080, J:12548, J:22485)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 44 strains available      Cell Lines: 0 lines available
Carrying any Ptprc Mutation:  58 strains or lines available
References
Original:  J:12077 Komuro K, et al., Ly-5: a new lymphocyte antigen system. Immunogenetics. 1975;1:452-456
All:  125 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory