Tg(APOE-DGAT2)29Far
Transgene Detail

Summary

• Symbol: Tg(APOE-DGAT2)29Far
• Name: transgene insertion 29, Bob Farese
• MGI ID: MGI:4819807
• Synonyms: Liv-DGAT2-high
• Transgene: Tg(APOE-DGAT2)29Far Location: unknown
• Alliance: Tg(APOE-DGAT2)29Far page

Transgene origin

• Strain of Origin: C57BL/6NHsd

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOE-DGAT2)29Far expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DGAT2 (84649)

  Dgat2

  (MGI:1915050)

• Mutation details: This transgene contains promoter and enhancer sequences of the human apolipoprotein E gene driving expression of a 1.2 kb human acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) cDNA. Mice from founder line 29 exhibit overexpression of DGAT2 mRNA/protein specifically in the liver. (J:94077, J:124005)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

It is not clear whether this is the same line called Liv-DGAT2-high in J:124005, as only two of five founder lines are analyzed therein and none are given line numbers. That line is said to have elevated expression of DGAT2 in the kidney and brain, as well as in the liver.(J:124005)

References

• Original: J:124005 Monetti M, et al., Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab. 2007 Jul;6(1):69-78
• All: 2 reference(s)