Tg(Bglap-TGFBR2*)E1Rdk
Transgene Detail

Summary

• Symbol: Tg(Bglap-TGFBR2*)E1Rdk
• Name: transgene insertion E1, Rik Derynck
• MGI ID: MGI:4819556
• Transgene: Tg(Bglap-TGFBR2*)E1Rdk Location: unknown
• Alliance: Tg(Bglap-TGFBR2*)E1Rdk page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Bglap-TGFBR2*)E1Rdk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TGFBR2 (7048)

  Tgfbr2

  (MGI:98729)

• Mutation details: A1.8 kb rat osteocalcin promoter fragment was used to direct expression of a truncated human cDNA encoding only the extracellular and transmembrane regions of the type II TGF-beta receptor. Eight of nine founders expressed the transgene. The four lines showing the highest expression levels were characterized. (J:57333)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:57333 Filvaroff E, et al., Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass. Development. 1999 Oct;126(19):4267-79
• All: 2 reference(s)