Tg(Bglap-TGFB2*C226S*C228S)D5Rdk
Transgene Detail

Summary

• Symbol: Tg(Bglap-TGFB2*C226S*C228S)D5Rdk
• Name: transgene insertion D5, Rik Derynck
• MGI ID: MGI:4819546
• Transgene: Tg(Bglap-TGFB2*C226S*C228S)D5Rdk Location: unknown
• Alliance: Tg(Bglap-TGFB2*C226S*C228S)D5Rdk page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Bglap-TGFB2*C226S*C228S)D5Rdk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TGFB2 (7042)

  Tgfb2

  (MGI:98726)

  Transgene codes for a protein with two cysteine to serine mutations.

• Mutation details: A 1.8 kb rat osteocalcin promoter fragment was used to direct expression of a human TGF-beta2 cDNA in osteoblasts. The TGF-beta2 cDNA was modified by two point mutations which changed the cysteines normally found at codons 226 and 228 to serines. Eight founders were produced but only founder lines D4 and D5 where characterized. (J:105791)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:105791 Erlebacher A, et al., Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype. J Cell Biol. 1996 Jan;132(1-2):195-210
• All: 1 reference(s)