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Tg(PMP22)C61Clh
Transgene Detail
Nomenclature
Symbol: Tg(PMP22)C61Clh
Name: transgene insertion C61, Clare Huxley
MGI ID: MGI:4819405
Transgene: Tg(PMP22)C61Clh  Location: unknown  Genetic Position: Chr10, Syntenic
Transgene
origin
Strain of Origin:  (C57BL/6J x CBA/Ca)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(PMP22)C61Clh expresses 1 gene
 
Mutation detailsA YAC containing the human PMP22 gene with 300 kb of upstream and 100 kb of downstream sequences was used as the transgene. STS analysis using 6 markers spanning the YAC showed the integrated transgene was largely intact including the region containing PMP22. Lines C1, C2, C16, C22, C58, and C61 were generated. (J:77330, J:78221)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:77330 Huxley C, et al., Correlation between varying levels of PMP22 expression and the degree of demyelination and reduction in nerve conduction velocity in transgenic mice. Hum Mol Genet. 1998 Mar;7(3):449-58
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory