Dclk2^tm1Jgg
Targeted Allele Detail

Summary

• Symbol: Dclk2^tm1Jgg
• Name: doublecortin-like kinase 2; targeted mutation 1, Joseph G Gleeson
• MGI ID: MGI:4819277
• Gene: Dclk2 Location: Chr3:86693458-86828159 bp, - strand Genetic Position: Chr3, 37.88 cM
• Alliance: Dclk2^tm1Jgg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148345
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was introduced to intron 1 and a loxP-flanked PGK-neomycin resistance cassette was placed in intron 2. (J:148345)

Generation of the Dclk2^tm1Jgg and Dclk2^tm1.2Jgg alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dclk2 Mutation: 134 strains or lines available

References

• Original: J:148345 Kerjan G, et al., Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6766-71
• All: 2 reference(s)