Tg(Thy1-PSEN1*G384A)45Jckr
Transgene Detail

Summary

• Symbol: Tg(Thy1-PSEN1*G384A)45Jckr
• Name: transgene insertion 45, Mathias Jucker
• MGI ID: MGI:4819105
• Synonyms: PS45
• Transgene: Tg(Thy1-PSEN1*G384A)45Jckr Location: unknown
• Alliance: Tg(Thy1-PSEN1*G384A)45Jckr page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-PSEN1*G384A)45Jckr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PSEN1 (5663)

  Psen1

  (MGI:1202717)

  Transgene codes for a protein with a glycine to alanine mutation.

• Mutation details: A human PSEN1 cDNA with a mutation in the codon for amino acid residue 384 causing a glycine to alanine change (G384A) was placed under the control of the murine Thy1.2 minigene. This mutant form is known to increase Abeta1-42 production. (J:92796, J:163811)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:92796 Herzig MC, et al., Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nat Neurosci. 2004 Sep;7(9):954-60
• All: 18 reference(s)