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Targeted Allele Detail
Symbol: Itga5tm2.1Hyn
Name: integrin alpha 5 (fibronectin receptor alpha); targeted mutation 2.1, Richard Hynes
MGI ID: MGI:4818933
Gene: Itga5  Location: Chr15:103344286-103366763 bp, - strand  Genetic Position: Chr15, 58.9 cM
Germline Transmission:  Earliest citation of germline transmission: J:161850
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA FRT-flanked Neo cassette and exon 1 were floxed by homologous recombination. The Neo cassette and exon 1 were removed by flp- and cre- mediate recombination respectively. (J:161850)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itga5 Mutation:  34 strains or lines available
Original:  J:161850 van der Flier A, et al., Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development. Development. 2010 Jul;137(14):2439-49
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory