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Targeted Allele Detail
Symbol: As3mttm1Djth
Name: arsenite methyltransferase; targeted mutation 1, David Thomas
MGI ID: MGI:4818883
Gene: As3mt  Location: Chr19:46695897-46729538 bp, + strand  Genetic Position: Chr19, 38.97 cM, cytoband D1
Germline Transmission:  Earliest citation of germline transmission: J:162148
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neo gene replaced exons 3 and 4 and possibly part of 5 by homologous recombination. The knock-out was confirmed by western blotting of liver lysates. (J:162148)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any As3mt Mutation:  14 strains or lines available
Original:  J:162148 Drobna Z, et al., Disruption of the arsenic (+3 oxidation state) methyltransferase gene in the mouse alters the phenotype for methylation of arsenic and affects distribution and retention of orally administered arsenate. Chem Res Toxicol. 2009 Oct;22(10):1713-20
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory