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Sgms2tm1Jia
Targeted Allele Detail
Nomenclature
Symbol: Sgms2tm1Jia
Name: sphingomyelin synthase 2; targeted mutation 1, Xian-Cheng Jiang
MGI ID: MGI:4818459
Synonyms: SMS2-
Gene: Sgms2  Location: Chr3:131318985-131491411 bp, - strand  Genetic Position: Chr3, 60.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:162226
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details90% of exon 2 was replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR on macrophage extracts. (J:162226)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sgms2 Mutation:  10 strains or lines available
References
Original:  J:162226 Hailemariam TK, et al., Sphingomyelin synthase 2 deficiency attenuates NFkappaB activation. Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1519-26
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory