Slc6a9^tm1.1Veul
Targeted Allele Detail

Summary

• Symbol: Slc6a9^tm1.1Veul
• Name: solute carrier family 6 (neurotransmitter transporter, glycine), member 9; targeted mutation 1.1, Volker Eulenburg
• MGI ID: MGI:4818449
• Synonyms: GlyT^-
• Gene: Slc6a9 Location: Chr4:117692240-117726502 bp, + strand Genetic Position: Chr4, 53.62 cM
• Alliance: Slc6a9^tm1.1Veul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161993
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin selection cassette was inserted in intron 2 and a third loxP was inserted in intron 4. The neomycin selection cassette was then removed by transient cre expression leaving exons 3 and 4 floxed. Subsequently, mice were crossed to Tg(EIIa-cre)C5379Lmgd mice to excise exons 3 and 4 creating a knockout allele. (J:161993)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc6a9 Mutation: 28 strains or lines available

References

• Original: J:161993 Eulenburg V, et al., Glial glycine transporter 1 function is essential for early postnatal survival but dispensable in adult mice. Glia. 2010 Jul;58(9):1066-73
• All: 1 reference(s)