Tg(CD2/HBB-TNF*)5453Gkl
Transgene Detail

Summary

• Symbol: Tg(CD2/HBB-TNF*)5453Gkl
• Name: transgene insertion 5453, George Kollias
• MGI ID: MGI:4818268
• Synonyms: delta 1-12, Tg5453
• Transgene: Tg(CD2/HBB-TNF*)5453Gkl Location: unknown
• Alliance: Tg(CD2/HBB-TNF*)5453Gkl page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD2/HBB-TNF*)5453Gkl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TNF (7124)

  Tnf	(MGI:104798)

• Mutation details: A mutant uncleavable form of the 26 kD protein was engineered by the deletion of the codons for the first to the twelfth amino acids of the wild type gene. This produces a membrane-associated protein that is bioactive. Under the control of the T cell specific human CD2 gene locus control region (LCR). (J:162144)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:162144 Georgopoulos S, et al., Transmembrane TNF is sufficient to induce localized tissue toxicity and chronic inflammatory arthritis in transgenic mice. J Inflamm. 1996;46(2):86-97
• All: 4 reference(s)