Dp(7Slx1b-Sept1)5Aam
Targeted Allele Detail
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Symbol: |
Dp(7Slx1b-Sept1)5Aam |
Name: |
duplication, Chr 7, Alea A Mills 5 |
MGI ID: |
MGI:4462823 |
Synonyms: |
16p11.2 dp, Dp(7)5Aam |
Gene: |
Dp(7Slx1b-Sept1)5Aam Location: Chr7:126288640-126832159 bp Genetic Position: Chr7, Syntenic
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Allele Type: |
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Targeted (Not Applicable) |
Mutations: |
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Duplication, Insertion
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Dp(7Slx1b-Sept1)5Aam involves 50 genes/genome features (Gm25333, Gm19288, Gm15676 ...)
View all
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Mutation details: Chromosome-engineering cassettes were inserted into mouse Chromosome 7, bracketing a span of approximately 0.39 Mb between the SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (Smg1) and the aldolase A, fructose-bisphosphate (Aldoa) loci. The cassette placed at the proximal locus contained Smg1, a puromycin resistance gene, a loxP site, a 3' portion of an hprt minigene and an agouti transgene. The cassette placed at the distal locus contained the Aldoa gene, a tyrosinase minigene, a 5' portion of an hprt minigene, a loxP site and neomycin resistance gene. Double-targeted ES cells were subjected to transient cre recombinase expression with subsequent selection of recombinants by using hypoxanthine aminopterin thymidine (HAT) media to produce a duplication of the targeted region.
(J:176335)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:176335 Horev G, et al., Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17076-81 |
All: |
8 reference(s) |
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