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Icktm1a(KOMP)Mbp
Targeted Allele Detail
Nomenclature
Symbol: Icktm1a(KOMP)Mbp
Name: intestinal cell kinase; targeted mutation 1a, Mouse Biology Program, UCDavis
MGI ID: MGI:4462529
Synonyms: Icktm1a
Gene: Ick  Location: Chr9:78109192-78172107 bp, + strand  Genetic Position: Chr9, 43.56 cM, cytoband E1
Endocrine-cerebro-osteodysplasia syndrome-like features in Icktm1a(KOMP)Mbp/Icktm1a(KOMP)Mbp mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Mutant Cell Lines:  DEPD00524_1_A09, DEPD00524_1_A10, DEPD00524_1_A11, DEPD00524_1_B09, DEPD00524_1_C09, DEPD00524_1_C10, DEPD00524_1_C11, DEPD00524_1_C12, DEPD00524_1_D09, DEPD00524_1_D11, DEPD00524_1_D12, DEPD00524_1_E09, DEPD00524_1_E12, DEPD00524_1_F09, DEPD00524_1_F10, DEPD00524_1_F11, DEPD00524_1_F12, DEPD00524_1_G09, DEPD00524_1_G10, DEPD00524_1_G12, DEPD00524_1_H09, DEPD00524_1_H10, DEPD00524_1_H11, DEPD00524_1_H12
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 78149985 of Chromosome 9 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 78150919. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157064)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Ick Mutation:  16 strains or lines available
Notes
The mice reported in J:211652 were created from the DEPD00524_1_A09 mutant cell line.
References
Original:  J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/05/2019
MGI 6.13
The Jackson Laboratory