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Tg(Flt3-cre)#Ccb
Transgene Detail
Nomenclature
Symbol: Tg(Flt3-cre)#Ccb
Name: transgene insertion, Conrad C Bleul
MGI ID: MGI:4462354
Synonyms: Flt3::Cre
Transgene: Tg(Flt3-cre)#Ccb  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsA sequence encoding cre together with an FRT-flanked kanamycin cassette was inserted into a BAC (RP24-145C8) into exon 1 of the Flt3 locus by ET cloning. Negative selection to identify properly targeted colonies was performed by transfection with an Flp recombinase-containing plasmid and selecting for kanamycin-sensitive colonies. Recombination was confirmed by sequencing and properly targeted BACs were injected into C57BL/6 pronuclei. Multiple lines were generated but no line numbers were specified. (J:136220)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Flt3     Summary of all recombinase alleles driven by Flt3.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:136220 Benz C, et al., The stream of precursors that colonizes the thymus proceeds selectively through the early T lineage precursor stage of T cell development. J Exp Med. 2008 May 12;205(5):1187-99
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory