Tg(Prnp*)EDah
Transgene Detail

Summary

• Symbol: Tg(Prnp*)EDah
• Name: transgene insertion E, David A Harris
• MGI ID: MGI:4462008
• Transgene: Tg(Prnp*)EDah Location: unknown
• Alliance: Tg(Prnp*)EDah page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp*)EDah expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prnp (MGI:97769)

• Mutation details: A cDNA encoding murine Prnp with an internal deletion of sequences encoding residues 105125 was placed under the control of a construct containing a Prnp promoter with an expression pattern similar to that of endogenous PrP, with the exception that there is no expression in cerebellar Purkinje cells. Lines A and B were also created. (J:117788)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:117788 Li A, et al., Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125. EMBO J. 2007 Jan 24;26(2):548-58
• All: 2 reference(s)