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Targeted Allele Detail
Symbol: Esr1tm1.1Rake
Name: estrogen receptor 1 (alpha); targeted mutation 1.1, Ruth A Keri
MGI ID: MGI:4461460
Synonyms: Ex3alphaERKO
Gene: Esr1  Location: Chr10:4611989-5005633 bp, + strand  Genetic Position: Chr10, 2.03 cM
Germline Transmission:  Earliest citation of germline transmission: J:161401
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsTwo loxP sites were inserted to flank Exon 3, the coding region for the DNA binding domain. Exon 3 was deleted by Cre-mediated recombination. (J:161401)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Esr1 Mutation:  14 strains or lines available
Original:  J:161401 Bernardo GM, et al., FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis. Development. 2010 Jun;137(12):2045-54
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory