About   Help   FAQ
Due to maintenance, access to MGI may be intermittent 8:00 AM ET Wed, September 18.
Sema6btm1Hfu
Targeted Allele Detail
Nomenclature
Symbol: Sema6btm1Hfu
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B; targeted mutation 1, Hajime Fujisawa
MGI ID: MGI:4461232
Gene: Sema6b  Location: Chr17:56123085-56140343 bp, - strand  Genetic Position: Chr17, 29.17 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:160509
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe sequence spanning most of exon 2 through 7 was replaced with a floxed neo cassette and farnesylated EGFP. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:160509)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sema6b Mutation:  17 strains or lines available
References
Original:  J:160509 Tawarayama H, et al., Roles of semaphorin-6B and plexin-A2 in lamina-restricted projection of hippocampal mossy fibers. J Neurosci. 2010 May 19;30(20):7049-60
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/05/2019
MGI 6.14
The Jackson Laboratory