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Tg(Igh-V-CD40lg)#Tsub
Transgene Detail
Nomenclature
Symbol: Tg(Igh-V-CD40lg)#Tsub
Name: transgene insertion, Takeshi Tsubata
MGI ID: MGI:4461029
Synonyms: CD154TG, CD40L/B
Transgene: Tg(Igh-V-CD40lg)#Tsub  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Igh-V-CD40lg)#Tsub expresses 1 gene
 
Mutation detailsAn Igh-V promoter, the Igh intron enhancer, and the Igk 3' enhancer were used to drive expression of the CD40lg cDNA. (J:128824)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Phenotypic Similarity to Human Syndrome: IBD- Inflammatory Bowel Disease

References
Original:  J:128824 Higuchi T, et al., Cutting Edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease. J Immunol. 2002 Jan 1;168(1):9-12
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory