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Slc4a8tm1.1Doel
Targeted Allele Detail
Nomenclature
Symbol: Slc4a8tm1.1Doel
Name: solute carrier family 4 (anion exchanger), member 8; targeted mutation 1.1, Dominique Eladari
MGI ID: MGI:4460780
Synonyms: Ndcbe-
Gene: Slc4a8  Location: Chr15:100761747-100823968 bp, + strand  Genetic Position: Chr15, 56.39 cM, cytoband F3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:161474
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre mediated recombination removed exon 12 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:161474)
Generation of the Slc4a8tm1.1Doel allele
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc4a8 Mutation:  21 strains or lines available
References
Original:  J:161474 Leviel F, et al., The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice. J Clin Invest. 2010 May 3;120(5):1627-35
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory