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Targeted Allele Detail
Symbol: Slc4a8tm1.1Doel
Name: solute carrier family 4 (anion exchanger), member 8; targeted mutation 1.1, Dominique Eladari
MGI ID: MGI:4460780
Synonyms: Ndcbe-
Gene: Slc4a8  Location: Chr15:100761747-100823968 bp, + strand  Genetic Position: Chr15, 56.39 cM, cytoband F3
Germline Transmission:  Earliest citation of germline transmission: J:161474
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsCre mediated recombination removed exon 12 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:161474)
Generation of the Slc4a8tm1.1Doel allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc4a8 Mutation:  29 strains or lines available
Original:  J:161474 Leviel F, et al., The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice. J Clin Invest. 2010 May 3;120(5):1627-35
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory