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Gt(ROSA)26Sortm6(Gli1)Amc
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm6(Gli1)Amc
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 6, Andrew P McMahon
MGI ID: MGI:4460761
Synonyms: R26-Gli1, RosaGli1-FLAG
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:121411
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129 and C57BL/6 and CBA and Swiss Webster
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Gt(ROSA)26Sortm6(Gli1)Amc expresses 1 gene
 
Mutation detailsA full-length Gli1 with a C-terminal 3X FLAG tag as well as an IRES2-Venus were inserted into the locus upstream of a floxed neo selection cassette. Upon cre expression, the cassette is removed and FLAG tagged Gli1-Venus is expressed. (J:121411)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  741 strains or lines available
Notes
ES cell line = YFP3.1, a male ES cell line carrying Tg(CAG-cre/Esr1*)5Amc and is compound heterozgous at Gt(ROSA)26Sor: Gt(ROSA)26Sortm1Sor and Gt(ROSA)26Sortm1(EYFP)Cos.
References
Original:  J:121411 Vokes SA, et al., Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development. 2007 May;134(10):1977-89
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory