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Neurog3tm3Ggr
Targeted Allele Detail
Nomenclature
Symbol: Neurog3tm3Ggr
Name: neurogenin 3; targeted mutation 3, Gerard Gradwohl
MGI ID: MGI:4460088
Synonyms: Ngn3flox
Gene: Neurog3  Location: Chr10:62133090-62134763 bp, + strand  Genetic Position: Chr10, 32.35 cM, cytoband B4
Loss of enteroendocrine cells in Neurog3tm1Fgu/Neurog3tm3Ggr Tg(Vil-cre)20Syr/0 and Neurog3tm3Ggr/Neurog3tm3Ggr Tg(Vil-cre)20Syr/0 mice

Show the 6 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:161480
Parent Cell Line:  P1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of the coding exon, and an frt and loxP flanked neo cassette was inserted downstream of the coding exon. Flp mediated recombination removed the neo cassette leaving the coding exon floxed. (J:161480)
Generation of the Neurog3tm3Ggr allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Neurog3 Mutation:  14 strains or lines available
References
Original:  J:161480 Mellitzer G, et al., Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival. J Clin Invest. 2010 May 3;120(5):1708-21
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory