Neurog3tm3.1Ggr
Targeted Allele Detail
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Symbol: |
Neurog3tm3.1Ggr |
Name: |
neurogenin 3; targeted mutation 3.1, Gerard Gradwohl |
MGI ID: |
MGI:4460088 |
Synonyms: |
Ngn3flox |
Gene: |
Neurog3 Location: Chr10:61968869-61970542 bp, + strand Genetic Position: Chr10, 32.35 cM, cytoband B4
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Alliance: |
Neurog3tm3.1Ggr page
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Loss of enteroendocrine cells in Neurog3tm1Fgu/Neurog3tm3.1Ggr Tg(Vil1-cre)20Syr/0 and Neurog3tm3.1Ggr/Neurog3tm3.1Ggr Tg(Vil1-cre)20Syr/0 mice
Show the 6 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:161480
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Parent Cell Line: |
P1 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A loxP site was inserted upstream of the coding exon, and an frt and loxP flanked neo cassette was inserted downstream of the coding exon. Flp mediated recombination removed the neo cassette leaving the coding exon floxed.
(J:161480)
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Generation of the Neurog3tm3.1Ggr allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Neurog3 Mutation: |
18 strains or lines available
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Original: |
J:161480 Mellitzer G, et al., Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival. J Clin Invest. 2010 May 3;120(5):1708-21 |
All: |
6 reference(s) |
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