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Rnf128tm1Cdon
Targeted Allele Detail
Nomenclature
Symbol: Rnf128tm1Cdon
Name: ring finger protein 128; targeted mutation 1, Chen Dong
MGI ID: MGI:4459531
Gene: Rnf128  Location: ChrX:139563316-139673145 bp, + strand  Genetic Position: ChrX, 61.35 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:160681
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 4 and all of exons 5 and 6 were replaced with the neomycin resistance gene by homologous recombination. This removed amino acids 283-385, which contains much of the RING domain from the protein product. RT-PCR analysis of various tissues confirmed the region was removed. (J:160681)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rnf128 Mutation:  5 strains or lines available
References
Original:  J:160681 Nurieva RI, et al., The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity. 2010 May 28;32(5):670-80
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory