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Igf1tm2.1Nros
Targeted Allele Detail
Nomenclature
Symbol: Igf1tm2.1Nros
Name: insulin-like growth factor 1; targeted mutation 1.1, Nadia Rosenthal
MGI ID: MGI:4459505
Gene: Igf1  Location: Chr10:87858265-87937042 bp, + strand  Genetic Position: Chr10, 43.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159167
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 was floxed and a FRT-flanked PGK-neomycin-resistance cassette was inserted within intron 3 before the 3' loxP site. The floxed exon and neomycin selection cassette were removed by cre-mediated recombination. No IGF-1 transcripts were detected by RT-PCR of liver tissue. (J:159167)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igf1 Mutation:  14 strains or lines available
References
Original:  J:159167 Temmerman L, et al., Class 2 IGF-1 isoforms are dispensable for viability, growth and maintenance of IGF-1 serum levels. Growth Horm IGF Res. 2010 Apr 8;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory