Slitrk5^tm2Vlcg
Targeted Allele Detail

Summary

• Symbol: Slitrk5^tm2Vlcg
• Name: SLIT and NTRK-like family, member 5; targeted mutation 2, Velocigene
• MGI ID: MGI:4459459
• Gene: Slitrk5 Location: Chr14:111912547-111920576 bp, + strand Genetic Position: Chr14, 57.86 cM, cytoband E3
• Alliance: Slitrk5^tm2Vlcg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160616
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Velocigene technology was used to replace the coding region with TM-lacZ and selection cassette, inserted at amino acid 47 after the initiator methionine, amino acid 7 after the signal sequence cleavage site. LacZ expression was detected in mice. (J:160616)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slitrk5 Mutation: 47 strains or lines available

References

• Original: J:160616 Shmelkov SV, et al., Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice. Nat Med. 2010 May;16(5):598-602, 1p following 602
• All: 3 reference(s)