Pitx2^tm5Jfm
Targeted Allele Detail

Summary

• Symbol: Pitx2^tm5Jfm
• Name: paired-like homeodomain transcription factor 2; targeted mutation 5, James F Martin
• MGI ID: MGI:4459127
• Synonyms: Pitx2^LacZ
• Gene: Pitx2 Location: Chr3:128993527-129013240 bp, + strand Genetic Position: Chr3, 57.84 cM
• Alliance: Pitx2^tm5Jfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160540
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 5, which encodes a portion of the homeodomain, was disrupted by the insertion of a cassette containing IRES, lacZ, and neo. Whole mount staining analysis confirmed the expression of LacZ in the heart. (J:160540)

Expression

In Mice Carrying this Mutation:

19 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pitx2 Mutation: 42 strains or lines available

References

• Original: J:160540 Wang J, et al., Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9753-8
• All: 1 reference(s)