About   Help   FAQ
Trp53tm2.1Rivm
Targeted Allele Detail
Summary
Symbol: Trp53tm2.1Rivm
Name: transformation related protein 53; targeted mutation 2.1, National Institute of Public Health and Environmental Protection (RIVM)
MGI ID: MGI:4457012
Synonyms: TgH(Tp53.hex4.72P)rivm, Trp53tm2.1Hvs
Gene: Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Alliance: Trp53tm2.1Rivm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94077
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsThis allele contains exon 4 of the human TRP53 gene, with the human proline variant at codon 72 (dbSNP:rs1042522; 72P). Codon 270, in the unmodified exon 8 - corresponding to human TRP53 codon 273 - encodes arginine (270R; mouse wild-type). A single loxP site in intron 1 is retained from an excised loxP-flanked translational STOP and selection cassette. (J:94077)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  232 strains or lines available
References
Original:  J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory