Tg(tetO-HTLV1-Tax)1Wcg
Transgene Detail
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Symbol: |
Tg(tetO-HTLV1-Tax)1Wcg |
Name: |
transgene insertion 1, Warner Greene |
MGI ID: |
MGI:4456222 |
Synonyms: |
Tet-o-Tax |
Transgene: |
Tg(tetO-HTLV1-Tax)1Wcg Location: unknown
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Alliance: |
Tg(tetO-HTLV1-Tax)1Wcg page
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Transgene Type: |
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Transgenic (Inducible, Inserted expressed sequence) |
Inducer: |
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doxycycline/tetracycline |
Mutation: |
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Insertion
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Mutation details: This transgene contains a cDNA encoding the viral 40-kDa Tax transactivator protein of human T-lymphotropic virus, type I (HTLV-1; also called human T-cell leukemia virus, type I) under control of the Tet operon (tetO), which comprises seven copies of the tetracycline responsive element (TRE) upstream of the cytomegalovirus minimal promoter. In a bitransgenic mouse also expressing tTA (tet-off) or rtTA (tet-on) from a tissue-specific promoter, Tax is conditionally expressed in the absence or presence, respectively, of tetracycline.
(J:102153)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:102153 Kwon H, et al., Lethal cutaneous disease in transgenic mice conditionally expressing type I human T cell leukemia virus Tax. J Biol Chem. 2005 Oct 21;280(42):35713-22 |
All: |
1 reference(s) |
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