About   Help   FAQ
Targeted Allele Detail
Symbol: Abhd5tm1.1Rze
Name: abhydrolase domain containing 5; targeted mutation 1.1, Rudolf Zechner
MGI ID: MGI:4456205
Synonyms: Cgi-58-
Gene: Abhd5  Location: Chr9:122351608-122381524 bp, + strand  Genetic Position: Chr9, 73.03 cM, cytoband F4
Small size, glossy dry skin, and necrotic tail tip in Abhd5tm1.1Rze/Abhd5tm1.1Rze mice

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:160725
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 4 and a floxed neo cassette was inserted downstream of exon 7. Cre mediated recombination removed exons 4 through 7 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on carcass lipid droplet extracts. (J:160725)
Targeting strategy and generation of the Abhd5tm1.1Rze allele
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abhd5 Mutation:  3 strains or lines available
Original:  J:160725 Radner FP, et al., Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58). J Biol Chem. 2010 Mar 5;285(10):7300-11
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.0
The Jackson Laboratory