Abhd5tm1.1Rze
Targeted Allele Detail
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Symbol: |
Abhd5tm1.1Rze |
Name: |
abhydrolase domain containing 5; targeted mutation 1.1, Rudolf Zechner |
MGI ID: |
MGI:4456205 |
Synonyms: |
Cgi-58- |
Gene: |
Abhd5 Location: Chr9:122180681-122210589 bp, + strand Genetic Position: Chr9, 73.03 cM, cytoband F4
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Alliance: |
Abhd5tm1.1Rze page
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Small size, glossy dry skin, and necrotic tail tip in Abhd5tm1.1Rze/Abhd5tm1.1Rze mice
Show the 5 phenotype image(s) involving this allele.
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted upstream of exon 4 and a floxed neo cassette was inserted downstream of exon 7. Cre mediated recombination removed exons 4 through 7 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on carcass lipid droplet extracts.
(J:160725)
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Targeting strategy and generation of the Abhd5tm1.1Rze allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Abhd5 Mutation: |
20 strains or lines available
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Original: |
J:160725 Radner FP, et al., Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58). J Biol Chem. 2010 Mar 5;285(10):7300-11 |
All: |
2 reference(s) |
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