Cdkn1b^tm1Wcl
Targeted Allele Detail

Summary

• Symbol: Cdkn1b^tm1Wcl
• Name: cyclin dependent kinase inhibitor 1B; targeted mutation 1, Warren C Ladiges
• MGI ID: MGI:4455327
• Synonyms: Cdkn1b^1800Wcl, p27^V109G, P27V109G, P27 V109G Knock-in
• Gene: Cdkn1b Location: Chr6:134897364-134902476 bp, + strand Genetic Position: Chr6, 65.77 cM
• Alliance: Cdkn1b^tm1Wcl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94077
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Single point mutation
• Mutation details: The gene was modified by insertion of a loxP-flanked neomycin resistance cassette in intron 2 and replacement of T by G at nucleotide position 326, in exon 1, resulting in substitution of glycine for valine at amino acid position 109 of the protein (V109G), a variation that may be associated with progression of some human cancers. (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkn1b Mutation: 25 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 1 reference(s)