Tg(Neurog1-cre)1Jejo
Transgene Detail
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Symbol: |
Tg(Neurog1-cre)1Jejo |
Name: |
transgene insertion 1, Jane E Johnson |
MGI ID: |
MGI:4455179 |
Synonyms: |
N1457-Cre, Neurog1457-Cre, Ngn1::Cre |
Transgene: |
Tg(Neurog1-cre)1Jejo Location: unknown
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Alliance: |
Tg(Neurog1-cre)1Jejo page
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Transgene Type: |
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Transgenic (Recombinase) |
Mutation: |
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Insertion
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Tg(Neurog1-cre)1Jejo expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Neurog1 (MGI:107754) |
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Mutation details: The Neurog1 coding region in the BAC RP23 457E22 was replaced by recombineering methods with the coding sequence for cre recombinase. Pronuclear injection of the construct into (C57BL/6J x SJL/J)F1 fertilized eggs was used to generated transgenic mice. Founder mice were subsequently established. The transgenic mice were then bred to outbred ICR mice. When crossed with a reporter strain, cre activity mimics the endogenous gene expression patterns in specific populations of interneurons and some motor neurons in the neural tube between embryonic days 10-13. Also, Cre recombination occurs in Neurog1 lineages that include subpopulations of neurons in the olfactory bulb, hippocampus, cortex, thalamus, midbrain, cerebellum, and dorsal root and cranial ganglia.
(J:160255)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Neurog1
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:160255 Quinones HI, et al., Neurogenin 1 (Neurog1) expression in the ventral neural tube is mediated by a distinct enhancer and preferentially marks ventral interneuron lineages. Dev Biol. 2010 Apr 15;340(2):283-92 |
All: |
11 reference(s) |
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