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Targeted Allele Detail
Symbol: Lrp4tm2Her
Name: low density lipoprotein receptor-related protein 4; targeted mutation 2, Joachim Herz
MGI ID: MGI:4455050
Synonyms: Lrp4-
Gene: Lrp4  Location: Chr2:91457511-91513779 bp, + strand  Genetic Position: Chr2, 50.63 cM
Unilateral and bilateral kidney agenesis in Lrp4tm2Her/Lrp4tm2Her mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:156471
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExon 1, which encodes the signal peptide and the initiating ATG, was replaced with a neomycin stop cassette. No residual functional protein can be generated. (J:156471, J:160547)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrp4 Mutation:  8 strains or lines available
Original:  J:156471 Ohazama A, et al., A role for suppressed incisor cuspal morphogenesis in the evolution of mammalian heterodont dentition. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):92-7
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
The Jackson Laboratory