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Tg(Thy1-COP3/EYFP)4Gfng
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-COP3/EYFP)4Gfng
Name: transgene insertion 4, Guoping Feng
MGI ID: MGI:4454808
Synonyms: Thy1-vChR1-EYFP Line 4, Thy1-vChR1-YFP line 4
Transgene: Tg(Thy1-COP3/EYFP)4Gfng  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene
description
Transgene Type:    Transgenic (Reporter)
Mutation:    Insertion
 
Mutation detailsA fusion protein was created with a synthetic, mammalian codon-optimized, red-shifted channelrhodopsin-1 cDNA sequence derived from Volvox carteri (VChR1; GenBank accession number EU622855 [residues 1-300]) fused in-frame to the amino terminus of an enhanced yellow fluorescent protein sequence (EYFP). This enhanced fusion protein (VChR1::YFP) was placed downstream of the modified regulatory region of the "murine thy1.2 gene" (extending from the promoter to the intron following exon 4, excluding exon 3 and its flanking introns), and followed by a bovine growth hormone polyA signal. Mice derived from founder line 4 exhibit medium to high EGFP expression in layer 5 pyramidal neurons at cortex, CA1, and dentate gyrus of hippocampus, thalamus, superior colliculus, inferior culliculus, brainstem, amydagala and cerebellum. (J:160663)
Phenotypes
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:160663 Feng G, DDS for Tg(Thy1-COP3/EYFP)4Gfng. MGI Direct Data Submission. 2010;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory