Tg(Thy1-COP3/EYFP)8Gfng
Transgene Detail
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Symbol: |
Tg(Thy1-COP3/EYFP)8Gfng |
Name: |
transgene insertion 8, Guoping Feng |
MGI ID: |
MGI:4454791 |
Synonyms: |
Thy1-vChR1-EYFP Line 8, Thy1-vChR1-YFP line 8 |
Transgene: |
Tg(Thy1-COP3/EYFP)8Gfng Location: unknown
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Alliance: |
Tg(Thy1-COP3/EYFP)8Gfng page
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Transgene Type: |
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Transgenic (Reporter) |
Mutation: |
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Insertion
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Mutation details: A fusion protein was created with a synthetic, mammalian codon-optimized, red-shifted channelrhodopsin-1 cDNA sequence derived from Volvox carteri (VChR1; GenBank accession number EU622855 [residues 1-300]) fused in-frame to the amino terminus of an enhanced yellow fluorescent protein sequence (EYFP). This enhanced fusion protein (VChR1::YFP) was placed downstream of the modified regulatory region of the "murine thy1.2 gene" (extending from the promoter to the intron following exon 4, excluding exon 3 and its flanking introns), and followed by a bovine growth hormone polyA signal. Mice derived from founder line 8 exhibit high EGFP expression in layer 5 pyramidal neurons at cortex, CA1, CA3 and dentate gyrus of hippocampus, thalamus, superior colliculus, inferior culliculus, brainstem, amydagala and cerebellum.
(J:160659)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:160659 Feng G, DDS for Tg(Thy1-COP3/EYFP)8Gfng. MGI Direct Data Submission. 2010; |
All: |
2 reference(s) |
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