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Tg(CD4-CIITA)357Ccum
Transgene Detail
Nomenclature
Symbol: Tg(CD4-CIITA)357Ccum
Name: transgene insertion 357, Cheong-Hee Chang
MGI ID: MGI:4454654
Synonyms: CIITATg, CIITA Tg
Transgene: Tg(CD4-CIITA)357Ccum  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6J x SJL
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CD4-CIITA)357Ccum expresses 1 gene
 
Mutation detailsTransgenic mice express a FLAG-tagged type III isoform of human CIITA under the control of a CD4 promoter/enhancer cassette. Expression of the transgene is detected in CD4-positive T cells. An additional line, line 400, was also generated and shows a similar phenotype to line 357. (J:99357)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:99357 Patel DR, et al., Constitutive expression of CIITA directs CD4 T cells to produce Th2 cytokines in the thymus. Cell Immunol. 2005 Jan;233(1):30-40
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory