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Transgene Detail
Symbol: Tg(H2-Kb-Tcra,-Tcrb)P25Ktk
Name: transgene insertion P25, Kiyoshi Takatsu
MGI ID: MGI:4454446
Synonyms: P25 TCR-Tg
Transgene: Tg(H2-Kb-Tcra,-Tcrb)P25Ktk  Location: unknown  
Strain of Origin:  C57BL/6
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(H2-Kb-Tcra,-Tcrb)P25Ktk expresses 2 genes
Mutation detailsThe P25TCR transgenic mice contain a T-cell antigen receptor (TCR) that recognizes peptide 25 (aa 240-254) of Mycobacterium tuberculosis Antigen 85B bound to I-Ab under the control of the H-2Kb promoter. Specifically, two transgenes were created, each containing either cDNA encoding the Valpha5 or the Vbeta11 gene, and a polyadenylation (polyA) sequence. Line P25 was created. (J:94023)
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Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:94023 Tamura T, et al., The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model. Int Immunol. 2004 Dec;16(12):1691-9
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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