Tg(H2-K^b-Tcra,-Tcrb)P25Ktk
Transgene Detail

Summary

• Symbol: Tg(H2-K^b-Tcra,-Tcrb)P25Ktk
• Name: transgene insertion P25, Kiyoshi Takatsu
• MGI ID: MGI:4454446
• Synonyms: P25 TCR-Tg
• Transgene: Tg(H2-K^b-Tcra,-Tcrb)P25Ktk Location: unknown
• Alliance: Tg(H2-K^b-Tcra,-Tcrb)P25Ktk page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-K^b-Tcra,-Tcrb)P25Ktk expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: The P25TCR transgenic mice contain a T-cell antigen receptor (TCR) that recognizes peptide 25 (aa 240-254) of Mycobacterium tuberculosis Antigen 85B bound to I-Ab under the control of the H-2Kb promoter. Specifically, two transgenes were created, each containing either cDNA encoding the Valpha5 or the Vbeta11 gene, and a polyadenylation (polyA) sequence. Line P25 was created. (J:94023)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:94023 Tamura T, et al., The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model. Int Immunol. 2004 Dec;16(12):1691-9
• All: 24 reference(s)