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Trim32tm1Hdin
Targeted Allele Detail
Nomenclature
Symbol: Trim32tm1Hdin
Name: tripartite motif-containing 32; targeted mutation 1, Hao Ding
MGI ID: MGI:4453461
Gene: Trim32  Location: Chr4:65604986-65616238 bp, + strand  Genetic Position: Chr4, 34.43 cM, cytoband C1
Trim32tm1Hdin/Trim32tm1Hdin mice show delayed and impaired skeletal muscle regeneration

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159937
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced with a splice acceptor, IRES and beta-geo cassette. Western blot analysis confirmed the absence of protein expression in the mouse embryonic fibroblasts. (J:184218)
Gene-targeting strategy for creating the Trim32tm1Hdin null allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trim32 Mutation:  1 strain or line available
References
Original:  J:159937 Liu Y, et al., Regulation of the psoriatic chemokine CCL20 by E3 ligases Trim32 and Piasy in keratinocytes. J Invest Dermatol. 2010 May;130(5):1384-90
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory