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Targeted Allele Detail
Symbol: Xirp2tm1Jl
Name: xin actin-binding repeat containing 2; targeted mutation 1, Jim J-C Lin
MGI ID: MGI:4453315
Synonyms: mXinbeta-, Xirp2-
Gene: Xirp2  Location: Chr2:67276343-67356964 bp, + strand  Genetic Position: Chr2, 39.31 cM
Alliance: Xirp2tm1Jl page
Germline Transmission:  Earliest citation of germline transmission: J:158491
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA portion of exon 6, intron 6 and a part of exon 7 were replaced with a LacZ-Neo cassette by homologous recombination. Northern blot and Western blot analysis revealed a complete loss of message and protein, respectively, in homozygous mice. (J:158491)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Xirp2 Mutation:  93 strains or lines available
Original:  J:158491 Wang Q, et al., Essential roles of an intercalated disc protein, mXinbeta, in postnatal heart growth and survival. Circ Res. 2010 May 14;106(9):1468-78
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory