Tg(KRT5-ATF3)1Mcld
Transgene Detail

Summary

• Symbol: Tg(KRT5-ATF3)1Mcld
• Name: transgene insertion 1, Michael C MacLeod
• MGI ID: MGI:4452619
• Synonyms: BK5.ATF3
• Transgene: Tg(KRT5-ATF3)1Mcld Location: unknown
• Alliance: Tg(KRT5-ATF3)1Mcld page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT5-ATF3)1Mcld expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATF3 (467)

  Atf3	(MGI:109384)

• Tg(KRT5-ATF3)1Mcld expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cattle	KRT5 (281268)

• Mutation details: This transgene contains the bovine keratin 5 promoter driving expression of a full length cDNA representing the long transcript of human activating transcription factor 3 (ATF3). Strong expression of the human protein was observed in the nuclei of basal cells of the epidermis, hair follicles and oral mucosa. (J:121782)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:121782 Wang A, et al., Epidermal hyperplasia and oral carcinoma in mice overexpressing the transcription factor ATF3 in basal epithelial cells. Mol Carcinog. 2007 Jun;46(6):476-87
• All: 3 reference(s)