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Crhtm1(cre)Zjh
Targeted Allele Detail
Nomenclature
Symbol: Crhtm1(cre)Zjh
Name: corticotropin releasing hormone; targeted mutation 1, Z Josh Huang
MGI ID: MGI:4452089
Synonyms: CRF-iCre, CRF-ires-Cre, CRH-iCre, CRH-ires-CRE
Gene: Crh  Location: Chr3:19693401-19695396 bp, - strand  Genetic Position: Chr3, 5.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:151755
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Project Collection: Neuroscience Blueprint cre
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert an internal ribosome entry site (IRES), a Cre recombinase sequence, a polyA sequence, and an frt-flanked neo cassette into the 3' untranslated region (after the translational termination site) of the corticotropin releasing hormone locus (Crh). The mice were bred to actin-Flpe animals to remove the neo cassette and the Flpe transgene was subsequently bred out of the line. (J:151755)
Recombinase
activity
Activity:
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Driver: Crh     Summary of all recombinase alleles driven by Crh. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 7 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crh Mutation:  15 strains or lines available
References
Original:  J:151755 NIH Neuroscience Blueprint Cre Driver Network, Cre recombinase-expressing mice generated for the NIH Neuroscience Blueprint Cre Driver Network. MGI Direct Data Submission. 2009;
All:  41 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory