About   Help   FAQ
Targeted Allele Detail
Symbol: Cd4tm4.1Litt
Name: CD4 antigen; targeted mutation 4.1, Dan R Littman
MGI ID: MGI:4452055
Synonyms: E4T-
Gene: Cd4  Location: Chr6:124864692-124888221 bp, - strand  Genetic Position: Chr6, 59.17 cM
Germline Transmission:  Earliest citation of germline transmission: J:158962
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Modified regulatory region)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe thymocyte enhancer downstream of exon 10 was replaced with an frt flanked hygro cassette. Flp mediated recombination removed the hygro cassette. (J:158962)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd4 Mutation:  65 strains or lines available
Original:  J:158962 Chong MM, et al., Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. Genes Dev. 2010 Apr 1;24(7):659-69
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory