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Targeted Allele Detail
Symbol: Cnot6tm1a(KOMP)Wtsi
Name: CCR4-NOT transcription complex, subunit 6; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4451305
Gene: Cnot6  Location: Chr11:49562330-49603550 bp, - strand  Genetic Position: Chr11, 29.76 cM
Mutant Cell Lines:  EPD0287_1_A05, EPD0287_1_A06, EPD0287_1_A07, EPD0287_1_B06, EPD0287_1_C05, EPD0287_1_D05, EPD0287_1_D06, EPD0287_1_D07, EPD0287_1_D08, EPD0287_1_E05, EPD0287_1_E06, EPD0287_1_E08, EPD0287_1_F05, EPD0287_1_F06, EPD0287_1_F07, EPD0287_1_F08, EPD0287_1_G05, EPD0287_1_G06, EPD0287_1_G07, EPD0287_1_H06, EPD0287_1_H07, EPD0287_1_H08
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 49577479 of Chromosome 11 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 49578192. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Cnot6 Mutation:  33 strains or lines available
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory