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Tjp1tm2a(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Tjp1tm2a(KOMP)Wtsi
Name: tight junction protein 1; targeted mutation 2a, Wellcome Trust Sanger Institute
MGI ID: MGI:4451268
Gene: Tjp1  Location: Chr7:64945913-65177529 bp, - strand  Genetic Position: Chr7, 35.02 cM
Alliance: Tjp1tm2a(KOMP)Wtsi page
IMPC: Tjp1 gene page
Mutation
origin
Mutant Cell Lines:  EPD0494_2_A09, EPD0494_2_A11, EPD0494_2_B09, EPD0494_2_C09, EPD0494_2_D11, EPD0494_2_E09, EPD0494_2_E11, EPD0494_2_F09, EPD0494_2_G09, EPD0494_2_G10, EPD0494_2_H09, EPD0494_2_H10
Germline Transmission:  Earliest citation of germline transmission: J:267500
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt0
 
Mutation detailsThe L1L2_gt0 cassette was inserted at position 64993139 of Chromosome 7 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 64993923. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Tjp1 Mutation:  66 strains or lines available
References
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory