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Acacbtm1.1Lowl
Targeted Allele Detail
Nomenclature
Symbol: Acacbtm1.1Lowl
Name: acetyl-Coenzyme A carboxylase beta; targeted mutation 1.1, Bradford B Lowell
MGI ID: MGI:4450932
Synonyms: Acc2flox
Gene: Acacb  Location: Chr5:114284596-114388822 bp, + strand  Genetic Position: Chr5, 55.97 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159285
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were positioned upstream of the preceding exon and downstream of the biotin binding domain exon, with an Frt flanked kanamycin resistance cassette inserted before the 3' loxP site. The Frt-flanked selection cassette was removed by Flpe recombinase-mediated recombination. Splicing of the remaining exons following Cre-mediated deletion would introduce a frameshift and nonsense mutation after Asp865 in any translated protein. (J:159285)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Acacb Mutation:  74 strains or lines available
References
Original:  J:159285 Olson DP, et al., Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7598-603
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory