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Tra2btm1.2Bwir
Targeted Allele Detail
Nomenclature
Symbol: Tra2btm1.2Bwir
Name: transformer 2 beta homolog (Drosophila); targeted mutation 1.2, Brunhilde Wirth
MGI ID: MGI:4450921
Synonyms: Sfrs10-
Gene: Tra2b  Location: Chr16:22244549-22266005 bp, - strand  Genetic Position: Chr16, 13.18 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159448
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA single loxP site and an frt flanked neomycin resistance cassette were inserted upstream of exon 4 and a second loxP site was inserted downstream of the exon. Exon 4 and the neomycin resistance cassette were excised in mice by crossing to the cre deleter line, Tg(CMV-cre)1Cgn. Deletion of exon 4 results in a frameshift and a premature stop codon in exon 5. (J:159448)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tra2b Mutation:  13 strains or lines available
References
Original:  J:159448 Mende Y, et al., Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn splicing. Hum Mol Genet. 2010 Jun 1;19(11):2154-67
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory