Tg(KRT5-HRAS)#Abal
Transgene Detail

Summary

• Symbol: Tg(KRT5-HRAS)#Abal
• Name: transgene insertion, Allan Balmain
• MGI ID: MGI:4450912
• Synonyms: K5ras
• Transgene: Tg(KRT5-HRAS)#Abal Location: unknown
• Alliance: Tg(KRT5-HRAS)#Abal page

Transgene origin

• Strain of Origin: B6CBF2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT5-HRAS)#Abal expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HRAS (3265)

  Hras	(MGI:96224)

• Tg(KRT5-HRAS)#Abal expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cattle	KRT5 (281268)

• Mutation details: A 1.3 kb truncated bovine keratin 5 promoter was used to drive a mutated human H-ras cDNA containing a Val at amino acid residue 12. Thirty founders were produced and 15 showed a skin phenotype. Four lines were studied in detail: KT932, KT754, KT760, and KT769. (J:49922)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:49922 Brown K, et al., The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted. Curr Biol. 1998 Apr 23;8(9):516-24
• All: 3 reference(s)